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Possible Side Effects of Quercetin
|From: Daniel Shoskes MD
|An anonymous patient wrote:
|I regret very much to inform you all that I have confirmed, in my
own mind at least, that quercetin treatment CAN be associated with
swelling and pain in joints, particularly the small joints of fingers and
|Dr. Shoskes replies:
Having never seen this in a patient of my own or in any of our
clinical trials it is hard to know exactly what this means. Two
The really horrible state of quality control of herbal products. I
am comfortable with Prosta-Q because I have seen the quality
control data myself.
See the recent article:
Daniel Shoskes MD
- At very high doses, antioxidants such as bioflavonoids can
actually become pro-oxidants. Combining quercetin with multiple
other anti-oxidant and anti-inflammatory products may have a net
pro-inflammatory effect in some people. Given the propensity for
distal joint pain, it may also be related to uric acid metabolism.
Free Radic Biol Med 1999 Dec;27(11-12):1313-23 Related
Articles, Books, LinkOut
Anti- and pro-oxidative effects of flavonoids on metal-induced lipid
hydroperoxide-dependent lipid peroxidation in cultured
hepatocytes loaded with alpha-linolenic acid.
Sugihara N, Arakawa T, Ohnishi M, Furuno K
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama
University, Hiroshima, Japan.
Lipid hydroperoxide (LOOH)-dependent lipid peroxidation was
induced in alpha-linolenic acid (LNA)-loaded hepatocytes by
adding Fe, Cu, V, or Cd ions at concentrations from 20 to 500
microM. The effects of structurally related flavonoids at
concentrations from 10 to 500 microM on the lipid peroxidation
The results with regard to each flavonoid
subclass are as follows:
- Flavonols such as myricetin, quercetin,
fisetin, and kaempferol, but not morin, showed dose-dependent
antioxidative activity against metal-induced lipid peroxidation at all
metal concentrations. Myricetin, quercetin, and fisetin were the
most effective antioxidants, although their efficacies depended on
the metal ion. Kaempferol and morin had antioxidative activity
equal to the other flavonols in the presence of Cu ions, but were
much less effective for the other three metal ions.
luteolin, apigenin, and chrysin were antioxidative at low Fe
concentrations, but were pro-oxidative at high Fe concentrations.
Luteolin exhibited antioxidative activity similar to that of
catechol-containing flavonols in the presence of the other three
metal ions. Apigenin and chrysin also acted as pro-oxidants with V
or with all metal ions, respectively.
- Taxifolin, a flavanone, also
showed both anti- and prooxidative activity, depending on Fe
concentrations, but with other metal showed only antioxidative
- Epigallocatechin, a flavanol, was antioxidative with
all metal ions, and its activity was similar to that of
catechol-containing flavonols. The various effects of flavonoids on
metal-induced lipid peroxidation in LNA-loaded hepatocytes is
discussed with regard to the change in redox potential of
Cleveland Clinic Florida
|This information is forwarded to you by the Prostatitis Foundation. We do not provide medical advice. We distribute literature and information relevant to prostatitis. While we encourage all research we do not endorse any doctor, medicine or treatment protocol. Consult with your own physician.
|© 2002 The Prostatitis Foundation |
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