| Causes of
Prostate Cancer or Chronic Prostatitis
Does prostatitis lead to
|Prostate diseases tend to
in order with prostatitis first, BPH second, and
prostate cancer. Prostatitis starts in young men who can be in their
teens, 20s, 30s, or 40s. BPH tends to occur in men
50 and prostate cancer is most often diagnosed in men in their 60s or
So, does prostatitis lead to prostate cancer?
One study showed an increased risk of prostate cancer in men with
symptomatic prostatitis. See:
Nakarta S: Study of risk factors for prostatic cancer.
Hinyokika Kiyo 1993;39(11):1017-1024.
Another study found that: "The relative odds of prostate cancer were
elevated in men with history of any type of prostatitis." But the study
was not good enough to be conclusive. See:
Roberts RO, Bergstralh EJ, Bass SE, Lieber MM, Jacobsen SJ.
Prostatitis as a risk factor for prostate cancer.
Epidemiology. 2004 Jan;15(1):93-9.
Another study found that: "Inflammation is frequently present in
prostate biopsies, radical
prostatectomy specimens and tissue resected for treatment of benign
prostatic hyperplasia." See:
Platz EA, De Marzo AM.
Epidemiology of inflammation and prostate cancer.
J Urol. 2004 Feb;171(2 Pt 2):S36-40.
Another study decided to look at whether antiinflammatories to curb
prostatitis, i.e. inflammation of the prostate, might help treat
prostate cancer. See:
Pruthi RS, Derksen JE, Moore D.
A pilot study of use of the cyclooxygenase-2 inhibitor celecoxib in
recurrent prostate cancer after definitive radiation therapy or radical
BJU Int. 2004 Feb;93(3):275-8.
See also this talk:
"Sexually Transmitted Infections and Prostatitis in the Etiology of
Prostate Cancer and Benign Prostatic Hyperplasia," an Epidemiology
thesis defense seminar with Siobhan Sutcliff; W4013 SPH. EB
Johns Hopkins Gazette
Prostatitis is often found when prostate cancer is removed. See:
Distribution of chronic prostatitis in radical prostatectomy specimens
with up-regulation of bcl-2 in areas of inflammation. Gerstenbluth RE,
Seftel AD, MacLennan GT, Rao RN, Corty EW, Ferguson K, Resnick MI. J
Urol. 2002 May;167(5):2267-70.
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2007 The Prostatitis Foundation
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