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Third International Chronic Prostatitis Network

Chlamydia pneumoniae as an impacting emerging pathogen in prostate pathologies

S. Mazzoli, A. Salvi, F. Guercini, M. Marongiu, A. Raugei
1 Centro MST, Ospedale S.M. Annunziata, Firenze, Italy
Istituto di Urologia, Universita’ degli Studi, Perugia, Italy
Istituto di Urologia, Universita’ degli Studi, Firenze, Italy
Chlamydia pneumoniae (C.p.) is one of the newest pathogens of the respiratory tract in humans. Every year almost 10% communicable pneumonitis are caused by this microorganism. The seroprevalence of C.p. in normal populations is high, estimated to be 50% at the age of fifthly, confirming its wide diffusion. Recently, C.p. has been connected with coronary chronic disease and myocardial infarction. Ver y recently C.p. has been found in patients with interstitial cystitis, a condition related to prostatitis. We have analyzed for the presence of C.p.DNA, by nested PCR, prostatic biopsies, EPS, post EPS urine, total ejaculate and first void early morning urine from patients affected by different prostatic pathologies: chronic abacterial prostatitis, benign prostatic hyper-plasia (BPH) and prostate cancer.
40 patients were included in the study and 87% resulted positive for Chlamydia pneumoniae DNA. 100% of the prostate biopsies (N. 10 patients) were positive, demonstrating the presence of the micro-organism inside the prostate gland both in prostatitis, BPH and prostate cancer patients.
Chlamydia pneumoniae, a microorganism inducing chronic body damages, has to be better studied in relation to chronic prostatic pathologies and prostate cancer. Several interrogatives remain also open: the role of machrophages and other immunologically related cells in transporting the microrganism inside the prostate gland and in modulating the infection; its persistence in relation to the various stages of prostate damage.
C.p. positivity in these chronic prostatitis, resistant to several therapeutic regimens of antibiotics, open new pharmacological approaches.
The constant presence of Chlamydia pneumoniae in all the prostate pathologies examined open a dis-cussion about the role of this microrganism in their development during the time: we postulate that the three conditions –prostatitis, BPH, prostate cancer– may represent different moment of the same process in which external conditions due to the host, espec-ially immunological conditions, can induce the deter-minism of the one instead of the other pathology.

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